Cucumis melo Enhances Enalapril Mediated Cardioprotection in Rats with Isoprenaline Induced Myocardial Injury

This study sought to investigate the cardioprotective potency and interaction of muskmelon (Cucumis melo) with enalapril (ENA) against myocardial damage caused by acute chronic isoprenaline (ISO) treatments in rats. In model, 150 mg/kg (s.c) ISO was administered for two consecutive days at end pretreatment either ENA, muskmelon, or both their respective groups. introduced into therapy ENA/muskmelon/ENA + groups during last 10 3 mg/kg. Muskmelon tested three doses (100, 200, 500 mg/kg, p.o., 30 days), one normal dose ENA (10 mg/kg) used. Blood samples were taken treatment, animals sacrificed. Biochemical markers such as LDH CK-MB, well antioxidant (superoxide dismutase (SOD) catalases) thiobarbituric acid reactive species (TBARS) measured serum heart tissue homogenate (HTH). To confirm biochemical findings, histological slides prepared. administration induced an elevation amount TBARS, which increased all it administered. Prior treatment resulted a rise biomarker activity homogenated decrease serum. terms alleviating abnormal conditions ISO, group given high combined had best outcomes. The activities SOD catalase substantially higher treated classes. Histological findings showing cytoprotective actions have confirmed outcomes models. It is therefore concluded that (500 has promising potential improved more efficiently injury model presence ENA.